register

News & Trends - Pharmaceuticals

Roche extends add-on evidence in breast cancer

Health Industry Hub | February 19, 2021 |
[Total: 1    Average: 5/5]

Pharma News: Findings from 6 years median follow-up in the APHINITY study confirm benefit in invasive disease-free survival (IDFS) from adding Roche’s Perjeta (pertuzumab) to standard adjuvant treatment in patients with node-positive, human epidermal growth factor receptor 2 (HER2)-positive early breast cancer.

The authors concluded that the second interim analysis of OS in the APHINITY study did not demonstrate a statistically significant OS benefit from adding Perjeta (pertuzumab) to standard chemotherapy plus Herceptin (trastuzumab) in HER2-positive early-stage breast cancer (p = 0.17); the number of OS events still remains relatively low.

The benefits of dual HER2 blockade using Perjeta (pertuzumab) and trastuzumab in the adjuvant setting for patients with node-positive disease observed at the primary analysis are reinforced in the updated analysis of IDFS. There is no evidence to justify the routine use of adjuvant dual anti-HER2 treatment for patients with node-negative early breast cancer.

Informa Telehealth Summit - Health Industry Hub supporting partner

Cardiac safety was confirmed with primary cardiac events remain <1% in both treatment groups.

The authors underlined that continued follow-up of patients is important to fully assess OS benefit at the time-driven third interim OS analysis planned for 2022.

To directly combat launch of biosimilar Herceptin, Roche in mid-2020 launched Phesgo, a fixed-dose combination of Herceptin and Perjeta, for HER2-positive breast cancer. The single-dose vial can be given in a treatment centre or at home, offering patients significant convenience. Previously, the two drugs had to be given separately. Phesgo is currently approved by the FDA and EMA, and awaiting TGA approval.


Medical

Medical Pharma Biotech MedTech - Achieving gender equity for female researchers - Professor Julie Campbell, GSK award winner

Achieving gender equity for female researchers – Professor Julie Campbell, GSK award winner

Health Industry Hub | August 6, 2021 |

Medical News: GSK Australia Award for Research Excellence (ARE) is one of the most prestigious and long-standing awards available to […]

More


News & Trends - Medical Technology

MedTech News - Baxter Healthcare launches on-site pop-up COVID vaccination clinic

Baxter launches on-site pop-up COVID vaccination clinic

Health Industry Hub | August 6, 2021 |

MedTech News: Baxter Healthcare has launched an on-site pop-up vaccination clinic at its Western Sydney site this week to support […]

More


News & Trends - Pharmaceuticals

Pharma News - Cancer treatments minimally impacted during COVID-19 lockdowns in Australia, new study

Cancer treatments minimally impacted during COVID-19 lockdowns in Australia, new study

Health Industry Hub | August 6, 2021 |

Pharma News: Australian cancer patients kept up their pharmaceutical treatments during last year’s COVID-19 lockdowns, a big data study from […]

More


News & Trends - Pharmaceuticals

Pharma News - Could PARP inhibitors benefit more ovarian cancer patients?

Could PARP inhibitors benefit more ovarian cancer patients?

Health Industry Hub | August 6, 2021 |

Pharma News: Researchers have made a discovery that could help more Australian women with ovarian cancer gain access to game-changing […]

More