Menarini completes acquisition of Stemline Therapeutics

Pharma News: Menarini Group, a privately held pharmaceutical and diagnostics company, completed the acquisition of Stemline Therapeutics, a commercial-stage biopharmaceutical company focused on the development and commercialisation of novel oncology therapeutics.

The $677 million transaction strengthens Menarini’s oncology portfolio with the addition of both commercial and clinical-stage assets.

Stemline launched ELZONRIS for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and paediatric patients, two years or older, following the approval by the United States Food and Drug Administration (FDA) in December 2018.

Elcin Barker Ergun, CEO of Menarini Group, commented, “We are very excited to complete the acquisition of Stemline and to welcome their accomplished team to Menarini. The addition of ELZONRIS, which has potential to treat many other malignancies, as well as the other attractive pipeline assets augments our research and development capabilities and will accelerate our efforts to deliver novel oncology therapeutics to patients in need.”

ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123), a target present on a wide range of malignancies. In parallel, Stemline has been evaluating ELZONRIS in clinical trials in additional indications including chronic myelomonocytic leukemia (CMML), myelofibrosis (MF), acute myeloid leukemia (AML), and others. Stemline’s additional pipeline candidates include felezonexor (SL-801) (XPO1 inhibitor; Phase 1 in advanced solid tumor patients ongoing) and SL-1001 (RET kinase inhibitor, IND-enabling studies ongoing).

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