register

News & Trends - Pharmaceuticals

Cosentyx narrowly misses superiority vs Humira in head-to-head psoriatic arthritis trial

Health Industry Hub | November 6, 2019 |

Cosentyx (secukinumab) “narrowly missed” achieving statistical significance for superiority compared to Humira (adalimumab) in the EXCEED head-to-head psoriatic arthritis trial.

While Cosentyx helped more patients numerically reach ACR20 – a benchmark on a commonly used scale from the American College of Rheumatology to measure joint swelling and more – its lead wasn’t statistically relevant, Novartis said.

“We view the results as confirming our vision of Cosentyx becoming standard of care in psoriatic arthritis,” Eric Hughes, Novartis’ global development head of immunology, hepatology and dermatology, said in a statement.

Cosentyx’s competitor – Lilly’s fellow IL17A drug Taltz – demonstrated superiority vs Humira last year in its own head-to-head study. In a study of psoriatic arthritis patients who hadn not yet been treated with a biologic, patients treated with Taltz showed more symptom improvement at week 24 than those who had taken Humira.

Lilly didn’t necessarily succeed specifically where Novartis failed. The trials were designed differently, and Novartis’ study was “the first-ever monotherapy head-to-head trial with a primary endpoint in psoriatic arthritis specific to joints,” Hughes’ statement said.

When it comes to psoriatic arthritis, Pfizer’s Xeljanz (Tofacitinib) is also a competitor in addition to its fellow JAK inhibitor Rinvoq (upadacitinib) from AbbVie which recently met primary and secondary endpoints in Phase III study in psoriatic arthritis.

You may also like Boehringer Ingelheim advances first pan-KRAS inhibitor into clinical testing

Register FREE to access Health Industry Hub’s e-news bulletin; the only one-stop-hub connecting Australia’s Pharma, MedTech and Biotech industry professionals and key stakeholders.


News & Trends - Pharmaceuticals

Federal court dismisses Arrotex dispute against Health Minister

Federal court dismisses Arrotex dispute against Health Minister

Health Industry Hub | July 12, 2024 |

Pharma News: The Federal Court has ruled against Arrotex Pharmaceuticals in their bid to challenge the Minister for Health and […]

More


News & Trends - Pharmaceuticals

Largest diabetes study reveals major benefits of dual therapy with SGLT2 inhibitors and GLP1 receptor agonists

Largest diabetes study reveals major benefits of SGLT2 inhibitors and GLP1 receptor agonists dual therapy

Health Industry Hub | July 12, 2024 |

Pharma News: Combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to […]

More


News & Trends - Pharmaceuticals

Queensland opens first regional CAR T-cell treatment centre

Queensland launches first regional CAR T-cell treatment centre

Health Industry Hub | July 12, 2024 |

Pharma News: Gilead Sciences and Lymphoma Australia have welcomed the opening of Australia’s first regional CAR T-cell treatment centre at […]

More


News & Trends - Pharmaceuticals

Government inaction leaves essential medicine shortages unresolved

Government inaction leaves essential medicine shortages unresolved

Health Industry Hub | July 12, 2024 |

Pharma News: Over the past 12 months, at least six essential medications and products have been withdrawn from the Australian […]

More


This content is copyright protected. Please subscribe to gain access.