register

Medical

Australia’s BCG vaccine trial to protect healthcare workers from COVID-19 gets boost from Gates Foundation

Health Industry Hub | May 5, 2020 |

An A$10 million grant from the Gates Foundation will allow the Murdoch Children’s Research Institute’s (MCRI) clinical trial of the BCG vaccine against COVID-19 to extend to 10,000 healthcare workers across Australia, Spain and The Netherlands.

The grant will allow the MCRI team to expand the BRACE trial from the original target of 4,000 healthcare workers.

In The Netherlands and Spain, the Radboud University Medical Center and UMC Utrecht will begin enrolling 4000 healthcare workers across 13 sites in the coming weeks.

The BRACE trial, which commenced on March 27, has already enrolled more than 2,500 workers in hospitals across Australia.

The multi-centre randomised controlled trial, which started at The Royal Children’s Hospital, will see half of healthcare workers given the BCG vaccine to test whether it can protect those exposed to SARS-CoV-2 from developing severe symptoms by boosting their ‘frontline’ immunity.

Register FREE and join 22,000+ industry professionals receiving the latest industry news and engaging content from Health Industry Hub, the ONLY one-stop-hub connecting Australia’s Pharma, MedTech and Biotech industry professionals.

BCG was originally developed against tuberculosis, and is still given to over 130 million babies worldwide each year for that purpose. The BRACE trial builds on previous research which showed that BCG can provide some protection against respiratory viral infections and a study in which BCG reduced virus levels and enhanced immunity to a virus with a structure of a similar type to SARS-CoV-2.

Professor Nigel Curtis, who leads the BRACE trial, thanked the Bill & Melinda Gates Foundation for generously supporting this research effort. Professor Curtis is a clinician-scientist who heads MCRI’s Infectious Diseases Research Group, Professor of Paediatric Infectious Diseases at The University of Melbourne and Head of Infectious Diseases at The Royal Children’s Hospital Melbourne.

“This funding will be crucial to quickly enable us to expand the BRACE trial to Sydney in Australia and The Netherlands and Spain internationally,” he said.

“It will be imperative to help our researchers show whether BCG vaccination improves ‘innate’ immunity in frontline healthcare workers to buy crucial time to develop and importantly, validate, a specific anti-COVID-19 vaccine.”

You may also like PRIME Awards 2020 call for entries – the only awards program dedicated to recognising excellence within Australian healthcare communications, is now open for entries.

Philanthropic support has allowed the trial’s rapid development and rollout in Australia. This support has included A$700,000 from Sarah and Lachlan Murdoch, A$400,000 from The Royal Children’s Hospital Foundation (RCHF), A$1.5M from The Minderoo Foundation and A$200,000 from the South Australian government.

Following the Melbourne launch of the trial in March, additional sites in Melbourne, Adelaide and Perth were announced in mid-April.

Professor Curtis said, “We have dealt with the pandemic extremely well in Australia with rapid and thorough physical distancing, contact tracing and quarantine where appropriate. This new funding from the Gates Foundation allows other countries to also test whether additional preventative measures may help protect healthcare workers.

“These sorts of trials normally take around eight to 12 months to start, but with the early support of philanthropy, we were able to start in record time within three weeks.

“Since beginning the BRACE trial we have been inundated with requests from other hospitals wanting to be involved, both in Australia and internationally. This funding will allow us to begin delivering on those requests.”

Professor Marc Bonten from UMC Utrecht said, “We are looking forward to collaborating with Professor Curtis and his team. We are very pleased to now be joining this international trial to see if BCG can help lessen COVID-19 symptoms in Dutch healthcare workers.”

Professor Mihai Netea echoed those sentiments saying, “At Radboud UMC we have spent more than 10 years investigating BCG’s off-target effects, including previous research with Professor Curtis. In a time of crisis such as this, we thank the Bill & Melinda Gates Foundation for their agile and generous contribution.”

Professors Curtis and Netea, along with WHO Director-General Dr Tedros Ghebreyesus, recently emphasised in a letter to The Lancet the need for BCG vaccine to only be given in the context of clinical trials when investigating its off-target effects. BCG vaccines are already in short supply, and indiscriminate use could jeopardise the supply needed to protect children against tuberculosis in high-risk areas.

In South Australia, recruitment at the Royal Adelaide and Women’s and Children’s Hospitals is coordinated through the South Australian Health and Medical Research Institute, and was enabled by a A$200,000 funding announcement from the South Australian state government and significant in-kind support from SAHMRI.

Three sites in Perth are coordinated by the Telethon Kids Institute, and funded by the Minderoo Foundation which contributed A$1.5 million.

The additional sites in Melbourne are at Monash Health and Epworth Health, and The Children’s Hospital at Westmead in Sydney.

MCRI Director, Professor Kathryn North, said, “The philanthropic leadership shown by our valued donors is vital to support urgent medical research at this critical time.”

“Australia has proven itself to be a global leader in ‘flattening the curve’ and we are pleased to now be in a position to help the rest of the world. We are still in a race against time.”


News & Trends - Pharmaceuticals

Clinicians unveil Novartis and BMS practice-changing trial results

Clinicians unveil Novartis and BMS practice-changing trial results

Health Industry Hub | June 24, 2024 |

Pharma News: Australia, known for its alarming melanoma rates, witnesses one person diagnosed with the disease every 30 minutes, and […]

More


News & Trends - Pharmaceuticals

Hearts4heart leads awareness week, amid progress in Boehringer Ingelheim and AstraZeneca therapies

Hearts4heart leads awareness week, amid progress in Boehringer Ingelheim and AstraZeneca therapies

Health Industry Hub | June 24, 2024 |

Pharma News: Heart failure is a significant health concern in Australia, affecting approximately half a million people, with over 67,000 […]

More


News & Trends - MedTech & Diagnostics

Cardiologists mark Australian first with Boston Scientific's intracoronary imaging system

Cardiologists mark Australian first with Boston Scientific’s intracoronary imaging system

Health Industry Hub | June 24, 2024 |

MedTech & Diagnostics News: Percutaneous coronary intervention (PCI) has faced substantial complications and failure rates, despite advances in medical devices […]

More


Leadership & Management

AbbVie New Zealand welcomes new leadership amid global moves

AbbVie New Zealand welcomes new leadership amid global moves

Health Industry Hub | June 24, 2024 |

Leadership & Management: In line with its global talent development plan, AbbVie has announced a significant change in leadership for […]

More


This content is copyright protected. Please subscribe to gain access.